Erythromycin loaded by tetrahedral framework nucleic acids are more antimicrobial sensitive against Escherichia coli (E. coli)

Erythromycin is a commonly used broad-spectrum antibiotic, but resistance to this antibiotic makes its use less effective. Considerable efforts, beside finding alternatives, are needed enhance antimicrobial effect and stability against bacteria. Tetrahedral framework nucleic acids (tFNAs), novel delivery vehicle with three-dimensional nanostructure, have been studied as carrying platform of antineoplastic drugs. In study, the tFNAs in delivering erythromycin into Escherichia coli (E. coli) was investigated for first time. The increased bacterial uptake promoted membrane destabilization. Moreover, it permeability cell wall, reduced drug by improving movement across membrane. tFNAs-based system enhanced effects E. coli. It may therefore provide an effective targeting antibiotic-resistant bacteria thick wall.